@sparklegram - I thought I could go the distance, at least 5 years. The first year was a breeze; the 2nd was as destructive as being hit by a Mack truck. My hands & feet are crippled (now I'm going to be tested for Rheumatoid & Lupis. From the Arimidex? Don't know yet. Yes, my oncologist told me that my ductal carcinoma insitu was caught very early; all my mammograms have been clean; bloodwork is good oncologically and he feels I will be fine with no more Arimidex. My quality of life has slipped to practically zero. Luckily for me, my God given gift is the ability to entertain myself, lol.