@randypixie – I am fortunate that my primary is in one of the local Mayo Family Health Clinics in a small town close to the Rochester Mayo Clinic Campus. I have had multiple experiences where my primary care doctor has referred me to a specialist at Rochester Mayo Clinic, What I have experienced is how well the different specialties work together to come up with a diagnosis by being patient centered.

I know it must be frustrating not having a diagnosis. If it is an option for you, I think Mayo Clinic Rochester would be an excellent choice. If you would like to seek help from Mayo Clinic, contact one of the appointment offices. The contact information for Minnesota, Arizona and Florida can be found here http://mayocl.in/1mtmR63.

Have you discussed the possibility of getting a referral from your wife's doctors?