Hello, I am 12 years post transplant and I was taken off tacrolimus about 5 years ago and placed on sirolmus. My transplant was done at Baylor Dallas. They claimed that the tacrolimus was more renal toxic. I have done great on sirolimus and last year I was taken off of Myfortic as well and still doing fabulous and feeling so much better with more energy, etc. I take only 1mg Sirolimus every other day and liver enzymes have not changed. Life is good.