Savella for Peripheral Neuropathy?

Hi @cwallen9, I don't have pain with my neuropathy just the numbness. I'm hoping someone that has experience will be able to share it with you. I was able to find some information that may be helpful.

Lyrica, Cymbalta and Savella: Do They Work?
-- https://www.painnewsnetwork.org/stories/2017/3/27/lyrica-cymbalta-savella-do-they-work

Milnacipran for pain in fibromyalgia in adults.
-- https://www.ncbi.nlm.nih.gov/pubmed/26482422

Hi, @cwallen9 - a few Connect members who've had mentioned milnacipran (Savella) for relief of fibromyalgia or other types of pain may have some input on its potential use for your peripheral neuropathy pain and share how it's worked in their situations, like @lioness @kaylg57 @pharis022 @jdrhoads @jmmb.

You mentioned no results yet with the milnacipran (Savella) as you just started on a very small dose. Have you noted any side effects?

Thanks for your reply. Yes, I have experienced severe side effects and have stopped it after only 5 days. It acted like a stimulant and made my neuropathy pain worse. It also made it more difficult to sleep. After discussing with my Pain Management Doctor, she agreed that I should go off it. I am now trying Elavil to complement the Gabapentin that I have been on for several months. I have only tried it for one day, but so far so good.

@cwallen9 Thank you Lisa I'm afraid I can't be to much help I was out on Savella awhile ago but went of it very soon after it didn't seem to be helping but to long ago to remember I know I didn't have any side effects

Hi unfortunately I wasn't on Savella long. I was weaning off my Cymbalta and going on the Savella. I wasn't feeling well so I just stuck with the Savella. I don't know if it was from the Cymbalta withdrawal.

Hi Peggy @peggyn, You might get a better response to your question if you posted it in the neuropathy discussion where more members will see your post:

> Groups > Neuropathy > Living with Neuropathy - Welcome to the group
-- https://connect.mayoclinic.org/discussion/living-with-neuropathy-welcome-to-the-group/

Here are a few articles that may provide some information on Savella (Milnacipran) that might be helpful for you.

Milnacipran for neuropathic pain in adults
-- https://www.cochrane.org/CD011789/SYMPT_milnacipran-neuropathic-pain-adults

Milnacipran for neuropathic pain in adults (Review) - Cochrane Library (PDF)
-- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011789/epdf/full

Are you considering using Savella for treatment?

<p>Has anyone taken savella for their neuropathy? I have never heard of it, but I met a lady the other day and that is what she takes. She said she had done them all and this one worked the best for her.. She sais it totally stops the burning in her feet.</p>

Hi @peggyn you may have noticed I moved your post to this discussion on savella for peripheral neuropathy so that you can connect with others who have similar experiences. Simply click VIEW & REPLY in your email notification to get to your post.

I wanted to thank @johnbishop for responding to your post, and also wanted to tag fellow Connect members @cwallen9 @kaylg57 @pharis022 and @jdrhoads as they have mentioned savella in the past and may be able to offer you support.

What are you currently on? How effective or ineffective is it? Have you started looking into setting up an appointment with your doctor to get their opinion?

I'm on lyrcia now..Sometimes I'm not sure it works as good as it could. I haven't mentioned to my dr. yet, as this lady just told me how much it helped her the other day.

I tried every different medication out the from Gabapentins to Cymbalta etc & all of those affected me terribly where my head was in one spot & my body was halfway across the room somewhere or I was having terrible dreams & having fits of anger at people. The Gabapentin had me so off balance I fell & broke my hip. I then started out on Topiramate which helped with the electric shock feeling of neuropathy a bit but not near enough. I asked to try something else, anything so Savella came next, didn't seem to do much @ 25mg 2x a day so I experimented with 50mg 2x a day, spoke to my doc about further experimenting, it was okayed, so now I'm up to 300mg per day, 100mg 3x a day. This dose has helped allot in reducing the burning sensations, the electric shock sensations. They are still there tho, just not near as bad & some days it's still hard to get them to a tolerable level where I can comfortably stand or walk around & accomplish some household chores etc. Most days I've been just unable to do much or even leave my house cause of the pain & numbness, now I'm not having to 'force' myself to do things so much. It does nothing for the numbness tho. Hope this helps anyone considering Savella, that likely you need to reach the higher does levels in order to achieve any relief results, please keep trying it. I've not yet experienced any side effects. I feel I could go up more in doseage but will wait to meet with my neurologist or msg her before I do on my own.