@gamesjr Hello Gene, and welcome. It's great that you want to be proactive about your health and that you are managing your sleep apnea. There are so many reasons for fatigue, and you might want to start with your primary physician to check heart and lung function, blood sugar and thyroid function. If your thyroid hormone levels are low, it causes lots of fatigue and effects your entire body, and I am familiar with that myself. You probably have a cardiologist, and it might not be a bad idea to communicate this to your specialists as well. I would also ask if you may be taking supplements that could contribute to fatigue such as melatonin? That can cause a "jet lag" effect because it induces sleep and can take a long time to wear off. I have an elderly mom (who also takes Eliquis), and I've learned some of her tricks, so I'll also ask if you are drinking enough water. That will cause fatigue if you are dehydrated and it puts a strain on your body. You should discuss this with your prescribing physician and your pharmacist and ask what your fluid intake should be each day. Lasix is used to pull water out of your body and would lower blood pressure, and it could cause dehydration if you are not balancing what your body needs with fluid intake. That's why you should discuss this with your doctor. Here's a link about Lasix. https://www.webmd.com/drugs/2/drug-3776-8043/lasix-oral/furosemide-oral/details