I also have a CF gene. I was diagnosed with Bronchiectasis, nocardia and Mac in 2003 at National Jewish Research Center. I was on the three meds for a year. Then was treated with bactram for a year for the nocardia. Been treated off and on thru the years for Nocardia. I finished another year on bactram about 6 months ago and have just recently been diagnosed with Mac again. So I’m back on the big 3 meds. I seem to tolerate the meds ok - just getting tired of always being on ‘something’. Sure glad I found this site . It does help to read and compare - especially how we all react to the meds. What works and what doesn’t.