@julieparton Hi Julie. In reading about the mutation you mentioned, it causes a decreased ability to detox the body and that heavy metals can accumulate. It talks about the process of methylation (detoxification) as being very inefficient and the master antioxidant that is produced is glutathione. There are suppliments for this and my doctor has me take one called Methyl CPG (Ortho Molecular) and another similar one is from Metagenics called Methycare. Both support healthy homocysteine levels. These supplements help heart patients. NAC (N-acetyly cysteine) is a precursor to glutathione. It might be that your body doesn't convert it to glutathione. I was reading about the mutation and you can have both or one of the MTHFR genes on the chromosome pairs. There are also glutathione supplements, and medical foods containing it for detoxing. My pharmacy sells them and my doctors have as well. There is also intraveneous chelation to remove metals from the body that some doctors offer. A good source for information might be the Environmental Health Center in Dallas. https://www.ehcd.com/ You can look up information, and they also have some expensive medical volumes written for doctors about treatment protocols for sale. These were written by the pioneer in the field Dr. Rea. My environmental medicine doctor recommended this and he follows these protocols.

Here are a couple links I found that explain the issues.
https://www.focusforhealth.org/mthfr-mutations/
https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000165142.37711.E7
https://www.amymyersmd.com/2017/07/what-is-an-mthfr-mutation-and-what-to-do-about-it/