I went through the Genesight company and my test was completely covered. I'm not positive if I was on Medicare at that time but I believe I was. My son got his test through MA and it was completely covered . If it's not covered, inquire of them what it would cost because the last time I spoke with them they had a sliding fee for people who didn't have insurance. You can waste a lot of money on a few months worth of drugs that don't work for you and put yourself through a lot of misery as well. I know nothing about Mayo's testing cost or what they test for but Genesight was the first on the market.