Hi @strikeanerve looks like you are new here. Do you think your fatigue and muscle tightness are peripheral neuropathy (PN) related? Do you have other symptoms? What is your overall history with respect to PN? My wife has had PN for 6 years (caused by chemo) and I have been her advocate, online researcher as well as sometime caregiver. She's overall much better now health wise than she was after chemo but her PN is still quite bad. She hated gabapentin and now does not take any drugs for pain. Best, Hank