Hello @sweede536. I also don’t have cancer but do get infusions of rituxan twice a year. I usually get pre-meds of dexamethesone infusion and benedryl before the infusions. You might ask the oncologists about the skin changes you’re having. Open sores and skin tears are good sites for infections. I would recommend wearing long sleeves and keeping your skin very clean. But, please check with your doctor.
This article talks about targeted therapies and skin reactions like you are getting with rituxan.