Some took 25 mg orally and some took 50 mg on Reddit forum. I'm on 25 mg but I have only been on it for 4 days so far. I also apply the topical solution that I made by grinding it up with a spoon (147 mg) in a bowl and add a little DMSO gel (70%) then apply it to my feet and calves. I actually have neuropathy up to my glutes. It's mostly on the backs of my legs but I have some on the fron of my knees and in the bend of the tops of my legs. I purchased it in Japan. I'm sure it will take a while to see results. Nerves only grow 1 mm a day. I have motor skill issues and weakness because I have large fiber damage as well as small fiber. Mine is auto-immune.