@marjou, I'm wondering if you ended up trying Trintellix? I have been on Prozac for over 15 years, and it stopped working for me about a year ago. I've been on almost every other psych medication (it feels like, anyhow). My psychiatrist recommended Trintellix awhile back. I'm considering trying it. How are you doing now? Have you tried anything to augment your Prozac (or did you try another medication)?