@merpreb Hello. I am so very sorry to hear of your husband’s travails with his improperly diagnosed illness! What a shame his probable histoplasmosis was not properly diagnosed and treated years ago! I hope that he will be seeing a knowledgable doctor now. My infectious disease doctor told me last year that the gold standard for a proper diagnosis of histoplasmosis was tissue, since blood and urine testing frequently come back negative, as was the case with me. I was diagnosed after a bone marrow biopsy which, mercifully, was done under anesthesia. If your husband’s doctor only orders blood and urine tests, I would insist on a tissue collection or change to another doctor. And I believe it would be most helpful for him to see an infectious disease specialist. I will be very surprised indeed if it turns out that your husband doesn’t have histoplasmosis, especially given his exposure to bird droppings from his study of pigeons. The treatment for histoplasmosis is to take Itraconazole, an antifungal, for up to a year. I sincerely hope you and your husband finds the help he needs! I wish you well also. Susan