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concerned over rising creatinine level.

Kidney & Bladder | Last Active: Mar 12, 2019 | Replies (49)

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@predictable

Does anybody know where we can get expert documentation of the kidney problems caused by Lisinopril? I'm now on a 40mg daily dose of Lisinopril, and I have been on it for years -- starting with 20mg daily dosage about 15 years ago. My hypertension has always been under treatment by a nephrologist, and all three of them are well known and highly respected. Not once have I received any advice that Lisinopril might cause kidney problems, and so far as I know, I have no symptoms attributable to it.

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Replies to "Does anybody know where we can get expert documentation of the kidney problems caused by Lisinopril?..."

@martin Jensen and everyone wondering about Lisinopril:

I've read and been told that ACE-inhibitors like Lisinopril can protect the kidney from renal hypertension (relieving glomerular pressure by lowering blood pressure, especially in diabetics.) But it also can decrease GFR because it blocks a protective mechanism which occurs in the kidney to maintain GFR.

So it seems to be a tossup - protect the kidney and improve function by controlling blood pressure vs protect the kidney's GFR status which MIGHT be impaired by the blood pressure med.

This is not medical advice or diagnosis, just my opinion based on my nurse's training as well as on fairly recent research done on my own.

I'm guessing my neph and primary both told me to stay on Lisinopril for now because they believe the benefits of lowering my blood pressure outweigh the risks of lowering GFR, especially since my GFR is above 30.

I'm also guessing that if my GFR declines too much we will have to seek alternatives.

Once again, these are just my own guesses and opinions based on a small amount of research.

Here are some websites with more information on the subject:
https://www.mdedge.com/clinicianreviews/article/134719/nephrology/when-discontinue-raas-therapy-ckd-patients
tmedweb.tulane.edu/pharmwiki/doku.php/ace_inhibitor_pharmacology
https://universityhealthnews.com/topics/heart-health-topics/3-ace-inhibitor-side-effects-should-you-seek-out-alternatives/