@rans, interesting. I was recently hospitalized for exacerbation COPD from a cold virus and my cr was a little higher than it was when drawn at last doc visit. My BUN and cr are elevated anyway (stage 3 CKD.) I, too take Lisinopril. Emailed some concerns about this to my doc, who had his office call to schedule appointment next week to discuss. Also, I take insulin for diabetes and a couple of other meds I need (a statin and an anti-depressant) interfere with insulin absorption. I feel like I'm always between a rock and a hard place, including renal diet vs diabetic diet. Very frustrating. Usually I have a positive attitude and stay cheerful while doing everything I can to balance it all but lately am feeling overwhelmed.