@bkruppa most ppl who have similar conditions to your wife's diagnosis according to what you wrote about the pudeal nerve in or around her sacrum area's. I'm not sure of the exact wording, for that I apologize. However I wanted to explain that there are many different conditions similar to your wife's issues that point to other area's that most ppl do not think could affect & cause similar areas to experience pain. Does she lose her bowels? If not that's not her issue. Also Taking Gabapentin aka Neurontin doesn't help has she tried Pregablin aka Lyrica also for nerve pain & diabetic Neuropathy.
Even Cymbalta works for some ppl. Has she tried a procedure called Rhizotomy or Radio Frequency Ablation yet? Ask your Neurologist & try to find a Neurosurgeon to look at all her MRI'S X-Rays etc.
I wish you & your wife less pain. I'm currently assisting my Husband w/his adjustment of his brand new Nevro HF10 Senza SCS which was implanted in January 18th, 2021.
He is at program #2 & level 3 & he is doing ALOT better. Pain & neuropathy levels dwn he already has about 70% RELEIF in his entire body, including his feet & toes. Im so happy for him. With this Brand you bring your remote & open up the back of remote there is a red button it turns everything off. This is great because you can use an X-ray & MRI, & CT Scans. & When done you put it back on. There is no parethesia but it is on, & just releif, but if there is cramping then it means it's overstimulated. Then he lowers the strength thru remote. But we call the Reps & they're more than willing to fix or answer any issue's. I wish you both well.