I did not realize how much the Prograf had affected me, as I have been taking it for 10 years! This has been my recent experience with it. Everyone noticed the positive change and I felt more like my old self again, although I know aging may affect it. Your body may react differently. My dose was decreased dramatically. Currently dose is back up and Cellcept added due to liver and kidney issues. I think we tend to forget what powerful meds we take.