@musicman2019 I was on tacrolimus after transplant and my creatinine started climbing. I was told to drink 80 - 100 ounces of fluid a day but that did not help much so they switched me to sirolimus. I still drink all of that water but I no longer have a creatinine problem. They really keep track of me, very thoroughly.
I also started having bad diarrhea while on tacrolimus. I was hoping with the change to sirolimus that would go away but it did not. I have come to realize that I now am lactose intolerant. I believe the tacrolimus must have triggered that since it happened right after starting tacrolimus.
JK