@electii I have completed over 12 months on Tymlos, and like you, have had migraine all my adult life. Drug reactions and multiple allergies have been ongoing issues for me. Perhaps my experience might be helpful. I suffered a compression fracture of the L4 two years ago, and it became shockingly clear that I, an active high altitude hiker, had severe osteoporosis. ( spine 4, hip 3.5 ). If I hoped to regain an active life, something had to be done. My endocrinologist prescribed Forteo. Two weeks later I had to stop Forteo due to an allergic reaction. Providentially, at that time, Tymlos had just come on the market. It felt reckless to try such a new drug, but I did. Nearly 13 months later, I am successfully tolerating Tymlos. I had a mild headache (not migraine) for a few days after starting Tymlos. Now, I have a bit of fatigue, and for a short time after the injection I am aware of my pulse. The best side effect was evident when I had a DEXA after 5 months. I had a profound increase in bone density. I am so thankful, and glad I did not give in to my fears. I totally understand the devastation and fear that drug reactions bring. I hope to complete two years with Tymlos. I send my best to you and hope you will soon be running again.