@teg These are strictly alternative medicine. However, there was a Japanese Pharmaceutical company called Takeda that sold it for many years. They discontinued as for the conditions they marketed Serrapeptidase it was not more effective than placebo. It wasn't a big part of their revenues. For purposes of clearing blood vessels of plaques and possibly helping tissues remodel, these may be very useful. Check out Serrapeptidase from Biomedix labs and Nattokinase from Doctors best on Amazon. Read the reviews and see what you think from people who use these. They helped me, I believe.