I did start to have anxiety, I believe mine was caused by lack of sleep. My functional medicine doctor prescribes drops of bio identical progesterone, which is not covered by my insurance but is only $34 for a bottle that lasts me over a month. It has not made me gain weight at all, I have more energy and feel like exercising whereas before I was a zombie and gained a bunch of weight. Personally I only take something (even supplements) that I have been tested for and prescribed. Just because something is "good for us" doesn't mean my body wants it or can handle it. Waking up at 3am every day like I did can signal an issue with liver, which has to process any supplement or medicine or food I take in, so I try to go easy on it.