My sister had knee surgery and after using CBD oil for a month she is not experiencing any improvement. What strength do you use and what is your dose? I find taking more than 4-5 drops daily of the 1000 mg isolate makes me too mellow and I'm not as productive. I've never used a tranquilizer, perhaps that is the effect it has on me. I now take mainly at night to minimize this and must admit I sleep deeper.