This is all very new and frustrating that its so rare. My husband is 64. He had a horrible reaction to the infusion Gazyva in Jan and spent a week in hosp (apparently with a unidentified infection). Now he is starting Venetoclax next week for a year. We will also get the infusions at some point. Is there anyone who has B-PLL who is familiar with this treatment? He doesn't have the 17p or TP53 mutations and has had the night sweats, weight loss, enlarged spleen and swollen lymph's.