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@81ue

Barbara - Correct. I asked my P.A. the last visit if I could go on Venetoclax (due to promising trials of taking both Venetoclax and Imbruvica or only Venetoclax) but was told they want to keep that or other next step drugs in reserve for when/if the imbruvica fails. I was thinking that if it could get myself to minimal residual disease that it would be good to blast the cancer now with all they got, but the dr and the specialist both were talking about plan A, plan B etc.and to keep treatment next steps in reserve. So for me, Venetoclax would be what I would ask for next since I have the 17p deletion. I don't want to have the stem cell transplant. For me I'll do anything before that - it's too scary to have bone marrow killed and then someone else's put in, Seems that the average is 60% success rate, so I'd have to save that as the last option The leukemia and lymphoma society page for B-PLL still says "While ibrutinib and idelalisib have not currently been FDA approved to treat B-PLL, they have been approved to treat other B-cell malignancies." But I'm already on Imbruvica now for a year and 4 months. They need to update pages and we need to push for drugs since we're not numerous enough to have our own clinical trials for B-PLL. In some clinical trials it seems we are allowed in with other conditions like CLL/SLL (I go to clincialtrials dot gov ). I already know that I'd not consider a clinical trial using fludarabine plus other drugs (it didn't work at all for me when dr's tried it on me)

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Replies to "Barbara - Correct. I asked my P.A. the last visit if I could go on Venetoclax..."

I went in on the 5th and again only one bag of blood. There is the possibility the reason has to do with the fact that I was on antibiotics up to that period.We'll see in 2 weeks, if all goes right .It's good that your Doctors are being cautious ,but still trying whatever is possible and correct. I have read that stem cell is not right for B-PLL; so don't even worry. Always check the internet before you start to think either pro or con.My fractured hip is healing very quickly. I can now put my full weight on my left foot,but due to ten years of arthritis ,my right knee is a problem that can't be treated due to the B-PLL.