Letrozole worked great for about 6 months but got tougher and tough on my joints. I took a month break after 2 years and then switched to Exemestane. It has been a terrific relief for me. 18 months and no biggie side effects!
I really feel each body has a different reaction to different aromatase inhibitors. I hope you find the right fit for your body❣️

@jkhambati
I started with anastrozole and lasted maybe 2-3 months...could hardly walk the pain was so great in my ankles, hands, and spine. I was next placed on letrozole and had extreme headaches as well as the pain and only made it a month before speaking to my oncologist. I've been on exemestane for about 1 1/2 years now and have been pretty much okay. Do have hot flashes and sometimes trouble with sleeping. Overall, however, this one for me is quite doable. I'm only taking a break now as I'm trying to get my weight down so will be off of it for about 1 month. Everyone reacts differently to medications so you will only know if you try. By all means though, speak up with your oncologist - if you don't talk to him/her, the oncologist won't know what is going on. Good luck...this adventure is not very easy!

I started with Anastrozole within about 4 months - My hands started with the join pain (also shoulders and toes!) that just got worse & worse. At about 6 months - after I discussed it with my oncologist, I went off it for 1 month. No change in the hand pain. She then had me go back on it & sent me to a Rheumatologist to see if I had RA in my hands. I finally got in about 8 weeks later, and she had to run her tests. By then I was at almost the 1 year mark for taking the Anastrozole. No arthritis - so she finally switched me to Exemestane. I have to say - it took my hand pain (at about a 7 daily) about 10 to 12 weeks to finally diminish. But it went down to about a 1 and sometimes it's zero. So my 1 year on Exemestane was in November. Like Trixie I still have hot flashes & insomnia but I think I can make the full 5 years now. I take CALM gummies for the insomnia - it really seems to work! It's just Magnesium.

Hi, I just wanted to share with you that I took Letrozole for 5years , and just recently was able to go off the medication. I was having a hard time with the side effects but ended up reading a thread on trying a different manufacturer. It was suggested by several to try Breckenridge and when I did it was so much better for me. I did take Turmeric and Glucosmine-Chondroitin daily. I would of course discuss with your doctor. Hope this helps you as much as it did me.💕