I am not sure which side effects you are referring to, anastrazole, or breast cancer? Since I have plenty of personal experience with both I will give you my experience and hindsight choices. Others no doubt will have different experiences and different choices. All of those are valid as we are all individual. My time with anastrazole was annoying, I had a slight nagging nausea for the first 4 to 6 months. I had some bone pain which is really annoying and uncomfortable. I also had a worsening of arthritis which can be annoying too. If it were not for the possibilities of cancer returning being higher I would never tolerate it. That being said, I went through cancer treatments for breast cancer and it was a grueling, painful year of agony. Beginning with multiple surgeries to chest, chest wall, and armpits. Moving on to aggressive chemotherapy, weight loss, hair loss, almost constant nausea, vomiting, and fatigue, added to the worry and anxiety. Next up another surgery to remove the ovaries, and on to radiation. Radiation includes burns and now scarring over chest wall, and crippling fatigue, being in the clinic every day Monday through Friday for 6 weeks. Rounding out the year with anxiety, fear and depression when the doctor said, ok , you are done, go live your life. Obviously knowing how I reacted to both of these things I would choose the very annoying years, over a year of agony. I have friends who had a different experience and would give you a wildly different story. The only person who can decide what is best for you, is you. Please seek out advice from your doctor, or a few doctors, then weigh your choices for yourself. I will be wishing you the best!