Update: 7 Weeks off Seroquel: It has been seven weeks since going off Seroquel. I have experienced extreme muscle fatigue. I have also experienced gastro issues which has been problematic. I had read where 95% of neurotransmitters are in your gut.......so it makes sense this is happening. I have been even keel with my moods which supports my theory that I am not bipolar but had a manic episode brought on my cold turkey stopping of Prozac after 15 years at 800 mg. Not the smartest thing I have ever done. Once in a great whie I will have an itchy feeling which Benedryl helps. Not bad like it was when I first went off.