I just joined this group. Diagnosed w/bipolar at age 25. Now 64. Have tried many drugs with psychiatrist over the years. Had to be hospitalized this pas July for the first time. Was prescribed 100 mg Seroquel, already taking lamictral and Lexapro, Dr. slowly increased to 400mg. Slowly working down. At 200mg now. Increase lamictral to 400. I have ALWAYS worked my psychiatrist in managing my meds. NEVER on my own. Yes, my libido was gone years ago, buy I have a very understanding husband. Seroquel has increased my appetite, but has made a big difference. Oh, well. Small price to pay. Yes, I have drive mouth, use Biotrin. It is vital to work with your psychiatrist. Someone mentioned hot flashes and night sweats. I appreciate that because I thought I was going through a second menopause-eek!!