I too gained 50 lbs on Seroquel. I started at 300 mg/day as an augment to Celexa. After I ballooned out, I tapered down to 200 and then 150 mg/day. Still no weight loss so I dropped to 100 mg/day and started getting withdrawal symptoms. So I went back up to 150 mg/day things seem to be stable, except for my weight which stubbornly insists on remaining at 50 lbs excess. I recently joined a gym and now I exercise 3-4 times a week. I'm also trying to cut back on calories by reducing meal portion sizes and not snacking between meals.

I don't understand how atypical antipsychotics cause weight gain. It is through an increase in appetite or some effect on the metabolism? My doctor doesn't seem to know and the information I find online is not very useful. Anyone know?