Hi @bac10,

I'm so sorry to hear about your daughter and all that your family is going through. As a parent myself, i can imagine how very worried you must be, especially with no definitive diagnosis! I'm also tagging Connect members @miche who along with @jhrbts and @lotsostufffailing talked about CVID or Common Variable Immune Deficiency; I hope they return with some more information that might help, as they had posted quite a while ago in this discussion:
– https://connect.mayoclinic.org/discussion/cvid/

I'd also like to introduce you to some of Connect's Mentors to see if they may have more insight; please meet @johnbishop @hopeful33250 @gailb and @windwalker.

In the meantime, I found two very informative papers on unexplained fever and recurrent infections in young children, which I'd sincerely encourage you to read. You can view both studies here:
– https://www.ncbi.nlm.nih.gov/pmc/articles/PMC261750/
– https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377046/

@bac10, I realize that this is stressful and that you're doing all that you can. We're here to help.