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JAK2 Mutation - Effects and Questions

Blood Cancers & Disorders | Last Active: Dec 18, 2023 | Replies (273)
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@nolan

I was diagnosed with Jak2 in 2019 and have been taking the hydra drug and I experience several side effects. Mouth ulcers, skin sores and irritations. Place me on antiviral meds to try to help prevent but still get these. I am experiencing extreme burning in my toes that is worsening. Is there anyone out there who has Experienced the burning in the toes or feet and what has been used to treat it?

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Replies to "I was diagnosed with Jak2 in 2019 and have been taking the hydra drug and I..."
Colleen Young, Connect Director | @colleenyoung | Feb 1, 2021

Hi @nolan, welcome to Mayo Clinic Connect. You'll notice that I moved your message to this existing discussion about the JAK2 (Janus kinase 2) gene mutation. I did this so you can connect with other members like @wa34937 @mjpm2406 @godschild56 @barbie75 and others.

Alterations in the JAK2 gene can cause conditions such as Crohn disease, essential thrombocythemia, polycythemia vera, primary myelofibrosis and others.

You mention that you've been prescribed hydroxyurea (Hydrea), which can cause the side effects that you describe like burning in hands and feet; leg wounds or ulcers; pain, itching, redness, swelling, or blisters on the skin; and mouth ulcers. Nolan, have you been diagnosed with essential thrombocythemia (ET) or polycythemia vera?

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