I had significant generalized pain, but when I now get Zometa I take Claritin few days before, day of and few days after. MUCH less discomfort. When I was on Darzalex I had similar pain. Took Claritin daily for the year. Without that help I wouldn't have been able to continue that protocol. Good luck with whatever it takes for you to find effective treatment. We are all so different. Will you let us know how you recover from this? Nancy