Hi @sierrawoods I just came across your post from 2018 about your experience of an adrenaline rush each night. I have been scouring the web for a few years trying to find a solution to exactly the same problem I just turned 54 but have been going through this problem for nearly 8 years An endocrinologist has had me wearing a freestyle libre glucose monitor for the past month and it has shown that my blood glucose drops low ( under 50) around 3 or 4 AM just as I have been experiencing the adrenaline rush sensation accompanied by high heart rate and at times sweating Although I am clearly entering perimenopause I do not have hot flashes during the day and I have eliminated nearly any prescriptions ( what’s on 12.5 MG atenolol daily for high heart rate and was trying bioidentical hormones for about a year) I am experiencing the same affects of the poor quality of sleep at night after night I like you drscribed. What years ago was only a few times a month has become a nightly thing for probably the past six months I wake up feeling as if I’ve been in an accident. The effect on my day is just as you described. I’m not exercising or even functioning efficiently. I am very slim and weight is not a problem, but I feel a great degree of fatigue and I’m pretty sure I have been sliding into a depression after seeing so many different doctors for years now and not being able to find any type of answer. It has a detrimental affect on my day (and now life) just as you described. I did have a brain MRI that showed a small nodule on my pituitary but the neurologist said not to worry about it. I remember you mentioning wanting to look into that for yourself on your post I hope you are doing better and I am just wondering if you have found any answers to this confounding, frustrating, and now debilitating situation. I just remarried about two years ago, my children are doing wonderfully, and I have very little stress in my daily life. This nightly occurrence is wrecking havoc on my life at what should be such a happy time. Just wondering if you have found any answers or additional information. Would sincerely appreciate any advice you may have. Thank you so much, and I hope you’re doing better.