yes I had no voice at all, I let my doc know , she said to stop inhaling for a few days, suck on strepfen(strepsils & neurofen losenger) and when I started back on it rince my mouth out after using the amakacin. I also inhaled at night so I diddnt have to talk after, just go to bed. Good luck with the Amakacin let us know how you get on.