Recurring lower-esophageal pressure, saliva and dry heaving

Posted by cwroblewski @cwroblewski, Oct 26 9:29pm

Summary

Since May 2025, I’ve experienced recurring episodes of intense pressure in my lower esophagus, accompanied by excessive saliva and repeated dry heaving. The pressure builds, and spitting saliva or dry heaving provides brief relief, but it quickly returns. I don’t experience typical heartburn or significant nausea.

Episodes can last 12–36 hours or longer, followed by days when I feel nearly normal. I’ve had two largely normal endoscopies and a normal-to-fast gastric emptying study. Esophageal manometry and 24-hour impedance-pH testing are scheduled for December 15–16.

I’m hoping to find someone who has experienced this specific combination of symptoms, particularly the recurring pressure and temporary relief from dry heaving.

More detailed history

I’m a 46-year-old male, physically active, and was generally healthy before these symptoms began rather suddenly in May 2025.

My symptoms tend to follow a recurring pattern:

* I can feel nearly normal for several days, eating comfortably and maintaining a good appetite.
* An uncomfortable pressure sensation develops in my lower esophagus, sometimes gradually over several hours.
* During a severe episode, the pressure becomes overwhelming. I frequently spit saliva into a cup because swallowing is the last thing I want to do.
* I may repeatedly dry heave, occasionally bringing up small amounts of clear fluid. The heaving briefly relieves the pressure, but it builds again.
* I don’t feel conventionally nauseated or sick to my stomach. It’s primarily an intense pressure sensation that makes me feel like I need to vomit, even though there’s little to bring up.
* Episodes sometimes continue overnight and can significantly disrupt my ability to eat, sleep, or function.
* Eventually, the pressure subsides, sometimes surprisingly quickly, and I can return to eating normally.

At times, these episodes have occurred roughly every five or six days. More recently, I’ve had days when the familiar pressure starts but never develops into a full episode.

Testing so far

* Two upper endoscopies: largely normal, apart from a small hiatal hernia and mild inflammation.
* Gastric emptying study: normal to somewhat fast.
* Upcoming December 15–16: high-resolution esophageal manometry and 24-hour impedance-pH monitoring to evaluate esophageal muscle function, sphincter relaxation, and acid/nonacid reflux.

I’ve also experimented with smaller, more evenly spaced meals and reducing overall daily food intake. This may help, but I haven’t established a consistent relationship between eating and the episodes. Once a severe episode begins, even prolonged fasting doesn’t reliably stop it.

My gastroenterologist also recommended a complete trial off THC to investigate whether it could be contributing. I’ve abstained since September 30, but episodes have continued.

What I’m hoping to learn from others

Has anyone experienced intense, recurring pressure specifically in the lower esophagus, accompanied by excessive saliva and dry heaving, but without significant nausea or classic heartburn?

Were you eventually diagnosed with an esophageal motility disorder, reflux hypersensitivity, nonacid reflux, or something else?

And most importantly, did you find a treatment that substantially reduced or eliminated the episodes?

I’d really appreciate hearing from anyone whose symptoms sound similar, especially if you’ve undergone esophageal manometry or impedance-pH testing.

Interested in more discussions like this? Go to the Digestive Health Support Group.

This may or may not be relevant. I've been having a lot of acid just at the base of my throat, with uncontrollable coughing and sometimes regurgitation. Diet and protonix don't help. A barium swallow test showed 5mm hiatal hernia and anterior c4-c7 bone spurs pressing against the esophagus. Unfortunately a bowel perforation and emergency resection with colostomy put my investigation on hold, but I hope to continue after reversal surgery. In the meantime, the high protein, low residue diet I'm on seems to have calmed everything down. I haven't even had a coughing fit in the past month.

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Have you had an upper GI study?Has your doctor looked into Superior Mesenteric Artery Syndrome (SMAS)? It’s a rare compression of the duodenum between the split pathways of the Mesenteric artery and aortic artery. Many things can disrupt gastric processing of food. My daughter has SMAS and during a flare-up, her stomach bloats and burns causing her to vomit excessively. I’m sorry you’re going through those terrible symptoms. Hoping for answers and a resolution for you soon!

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Sounds like me. I had similar tests. Waiting for mannonetry tests. I have a hiltal hernia. I was scoped about 10 years ago, no mention of a hernia so that may be new? I have not been responsive to Nexium either. Doctor said it is an atypical GERD that maybe just a catchall diagnosis. The throwing up without nausea is a very troublesome symptom. About 10 years ago, I had very difficult symptoms. I lost weight and my most severe symptoms lessened. Also incorporated exercise and I eliminated or greatly reduced trigger foods in my diet. I now find that I throw up less often, but that symptom varies, like a flare. Much more frequent is the pressure, burning sensation in the chest and some swallowing difficulties. Keep us posted on the site if you learn more and I will do the same.

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Hi @cwroblewski, welcome to Mayo Clinic Connect. I’m glad you found Connect and appreciate how thoughtfully you’ve described your experiences and what you’re hoping to learn from others.

These recurring episodes sound very difficult, especially when they interfere with eating, sleeping, and everyday activities. I can understand why you’re hoping to find others who recognize what you’re experiencing.

I noticed that @eloise999 has shared some similarities in her experience and is also awaiting esophageal manometry testing. I hope the two of you can connect and learn from each other’s experiences.

With your additional testing coming up in December, I hope you’ll continue sharing what you learn and how you’re doing along the way.

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