Hip Hip Hooray…It’s Chemo Day! 🎈🎈🎈

Hey, Hey, Hey...another infusion day. Cycle 3 Day 1

And, of course, can't be infusion day without a shirt.

@mjp0512
Hey Mike,
Good luck today with round three! I love the shirt—but honestly, you don’t need the chemo for that. The superpowers you already have—fortitude, perseverance, and that incredible sense of humor—will get the job done and are an absolute inspiration to everyone around you.
We are all cheering you on and sending you so much love today. You've got this!
Bill

@dailyeffort

I agree 100 % !!! 🥰👍
MJP has super powers by all means !!! 🦸‍♂️
That level of stamina and of high spirits in such a tough situation are really something to aspire to, but so hard to achieve for the vast majority of us.

Once more - best of luck Mjp and may this round be as uneventful as it can be ! I hope that Oxi is working well and that you had some sleep last night.
How is your leg ? I hope it is "behaving" and is not giving you much trouble : (.

Let us know how are you doing when you can <3.

@dailyeffort - Hi Bill. Thank you so much for your kindness. I have no words to express how much it means to me.

@surftohealth88 - Hi ya surf. Kind words indeed. Thank you.
Legs pretty much back to normal but they usually wig out on day 4 so we'll see what happens this go around. Oh...and there's no such thing as some sleep the night before infusion. The 16mg of dexamethasone they make you take the day before knocks out any chance of sleeping.

I did some quick "looking up " about mutations that you have and IA gave me this answer about TP53 . I specifically asked about this one since this tramples SPOP. SPOP regulates AR and BRAF but can not help with this particular TP53 mutation : (. For that reason I concentrated on TP53 .

Emerging Treatment Strategies:

• Combination Drug Regimens: Preclinical studies from institutions like the University of Michigan show promise using dual-drug approaches—such as combining BET bromodomain inhibitors with DNA methyltransferase (DNMT) inhibitors—to slow growth in transdifferentiated, treatment-resistant prostate tumors that have lost TP53 and RB1.
• Platinum-Based Chemotherapy: For aggressive variant prostate cancers often driven by combined TP53, RB1, and PTEN co-alterations, guidelines (such as NCCN) and clinical practice frequently utilize platinum-based chemotherapy regimens (such as cabazitaxel plus carboplatin).
• MDM2/4 Antagonists and p53-Restoring Compounds: Early-phase clinical trials are investigating small molecules designed to block MDM2/MDM4 (which degrade p53) or restore normal function to mutated p53 proteins.
• Genetically Targeted and Delivery Systems: Experimental gene therapies and novel delivery mechanisms (such as targeted nanoparticle or viral delivery of normal TP53 genes) are under early evaluation to re-sensitize resistant cells to standard chemotherapy and radiation.
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I hope this was of any help and perhaps can give you some ideas of what to ask MO. Perhaps platinum based chemo would work better IF this one does not give desired results.

PS: I am so sorry to hear that you could not sleep at all : (((, that sucks big time *sigh BUT your leg is well 🧿🍀 and as always with PC we all have to celebrate small victories *sigh
Wishing you good night sleep and manageable SAs of the third round ! Maybe the "third time's the charm" 👍🍀 !!!

@surftohealth88 - Thanks for the research, surf. Carboplatin combined with Jevtana (cabazitaxel) and prednisone has already been discussed. The question becomes how sick to I want to get to try and not be sick. Side effects are more severe and more difficult to manage. That's why I chose Taxotere first. I think my next step, should current treatment fail, is to let radiation oncology have a whack at it and see how much they can target. At least they should be able to knock out some of this bone pain. I need to do more research into the carbo/jevtana thing before I can agree to it.

My wife spent the last two years of her life fighting lung cancer. Metastatic to eyes, brain, and liver. Wills Eye Clinic and Abramson in Philly, Johns Hopkins in Baltimore. Chemo # 1,2, &3. Gamma knife times 4, liver radiotracer clinical trials and so on and so on. One thing she did not do was enjoy the time she had left. We spent all the time traveling to and from doctors and trials. And she was always fighting treatment side effects. I will not follow that path. At some point the chase ends. There is a line to be drawn. I'm not yet sure where that line is but when I get there, I am sure I will draw it.

On a more positive note, I stopped at the butcher on the way home from chemo and grabbed a really nice 2-inch T-Bone for when I can eat again in 10 days or so. 😁

@mjp0512 keep us up to date- we are all behind you and want you to win..so just know that !!

@mjp0512 Aside from all the poison, has your MO discussed BAT therapy at all? You might have one of those strains that can be shocked into submission. SE’s should be that you actually feel better! At least for a time, anyway…
If you’re gonna take a big swing…you might need a BAT😉
Phil

@heavyphil - Hi ya Phil. Bat therapy has been discussed. Twice as a matter of fact, old GUO and new GUO. As I've mentioned in the past, I'm also a heart failure patient. Since TRT has a tendency to muck around with heart rhythms, cardio-oncology asked that this be placed closer to a last resort status. While the TRAVERSE study lessened overall cardiac risk associated with TRT, BAT bounces T from low to high and the effect from this action on cardiac rhythm anomalies has not been thoroughly observed. My thought, how much worse could it be than injecting all this crap? I see cardio in about a week and a half. I'll bring it up again. Good idea, thanks!