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Treatment resistant depression help.

Transplants | Last Active: Dec 18, 2024 | Replies (135)

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SSRI had always worked for me. But over last few years I’ve had a lot stress in my life. My ARNP kept wanting me to change from lexapro to Zoloft which helped me totally recover from PPD years ago. The switch and Zoloft did not take. I went to a place I could never imagine. Drs have tried every drug and procedure and I’m still so bad sick and deemed TRD with severe anxiety. I worked for 38 years in same healthcare job and have been unable to work or function anymore. I’ve even been to Mayo.
Has anyone had something like this happen to them?

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Replies to "SSRI had always worked for me. But over last few years I’ve had a lot stress..."

Hi, I understand how frustrating this is and not being able to find the right treatment for your symptoms. My situation has similarities to yours but I eventually put a halt on the medications, many years ago I did have some good results from my medications but eventually I would get off them because either they didn’t help me anymore or I just wanted to try living life without them. I’m now still recovering from the last SSRI antidepressants that I used earlier this year and I had a bad reaction to them, of course my options were to try another one, I even tried a compound pharmacy to help with reducing the dosage to see if it would help reduce the side effects. I finally said enough and stopped taking them but I went into serotonin withdrawal syndrome and it’s been a long and miserable journey but I didn’t give in, I was shocked to learn how many people are going through the same thing, these medications are very difficult to get off them, you’re damned if you do and damned if you don’t. I still have some side effects from the withdrawal symptoms but not nearly as bad as it was before, there’s definitely a light at the end of the tunnel. I’m not saying that you should take the route I took but the alternative is a miserable experience of going around in circles until you find the magic pill, please look for a good doctor with lots of experience with medication or even an experienced pharmacist, I hope that you find the best help you so desperately need.

Yes, me, in the last few years. Have been on Effexor 300 mg a day for many years and it seemed to be working up until the last couple of years. Of course it was exacerbated by my partners, illness, and subsequent death now I’m finding even the addition of other meds, such as Abilify, etc. don’t work. We’ve tried three even an increase of 75 mg of Effexor didn’t work made me feel worse. I’m basically at my wits end and the only thing that helps is Ativan, which I’m afraid to take because I have bad memory loss lately. Has anyone found something that helped them in the situation, such as this?