Pathology interpretation help!
hi. I just received my Pathology results from my Fusion biopsy. Any help interpreting the results, suggestions, advice going forward would be much appreciated.
Final Pathologic Diagnosis
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A. Prostate, RLB, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 1 core(s) (2.8 mm greatest contiguous focus, 30% of tissue)
B. Prostate, RMB, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 1 core(s) (0.6 mm greatest contiguous focus, 5% of tissue)
C. Prostate, RLM, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 1 core(s) (4.2 mm greatest contiguous focus, 45% of tissue)
D. Prostate, RMM, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 1 core(s) (0.5 mm greatest contiguous focus, 5% of tissue)
E. Prostate, RLA, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 4 = 7 (Grade group 2, 10% pattern 4)
- Carcinoma involves 1 of 1 core(s) (4 mm greatest contiguous focus, 40% of tissue)
F. Prostate, RMA, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 1 core(s) (0.7 mm greatest contiguous focus, 5% of tissue)
G. Prostate, LLB, biopsy:
- Benign prostate tissue
H. Prostate, LMB, biopsy:
- Benign prostate tissue
I. Prostate, LLM, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 1 core(s) (2.8 mm greatest contiguous focus, 20% of tissue)
J. Prostate, LMM, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 1 core(s) (2.5 mm greatest contiguous focus, 20% of tissue)
K. Prostate, LMA, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 1 core(s) (2.5 mm greatest contiguous focus, 20% of tissue)
L. Prostate, LLA, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 4 = 7 (Grade group 2, 10% pattern 4)
- Carcinoma involves 1 of 1 core(s) (3 mm greatest contiguous focus, 45% of tissue)
M. Prostate, ROI 1, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 2 of 2 core(s) (3.5 mm greatest contiguous focus, 40% of tissue)
N. Prostate, ROI 2, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 4 = 7 (Grade group 2, 10% pattern 4)
- Carcinoma involves 2 of 2 core(s) (7.5 mm greatest contiguous focus, 60% of tissue)
O. Prostate, ROI 3, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 1 of 2 core(s) (2 mm greatest contiguous focus, 10% of tissue)
P. Prostate, ROI 4, biopsy:
- Prostatic adenocarcinoma, Gleason score 3 + 3 = 6 (Grade group 1)
- Carcinoma involves 2 of 2 core(s) (7.8 mm greatest contiguous focus, 85% of tissue)
Best block for ancillary testing: Block N1
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The first thing I did when I got biopsy was to copy and paste into AI , Claude, Gemini, chat, It will give you a clear explanation and you will be in a good position to research before you meet with your urologist and have questions.
It’s obvious that you have prostate cancer. My limited experience here but Gleason 7 is very treatable and highly curable. Just explore your options and don’t let your original doctor rush you into anything.
Books i found helpful. The key to prostate cancer, Scholz and Dr. Patrick Walsh’s guide to surviving prostate cancer. Walsh.
Good luck
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Hug
2 ReactionsAll the cores except 2 are positive. Even if you only have two 3+4 cores with relatively little pattern 4, the extent of the 3+3 cores means you should probably get treatment.
The good news is that is does not look very aggressive. You should get that confirmed with a Decipher test.
You should have plenty of treatment options and would likely be a goid candidate for some RT only to the prostate and without ADT. You could also look into whole gland Tulsa.
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Hug
3 ReactionsThis biopsy certainly validated your belief 18 months ago that something was up. If not for staying on top of it , you likely would not have gotten on to this as quickly. Certainly it would eventually have exposed itself. I went 18 months knowing something was amiss until it finally showed at my continued close monitoring of all my results.
Now clearly your cancer is diagnosed and overall your biopsy is favorable (except for cancer), but gives you time to review and educate yourself about your options which you do have. Next up your PET and Decipher.
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Hug
3 ReactionsI agree with @topf. Too many both 3+3 and 3+4. One rule is, if there’s over six of them then you need to do something. You have 14 cores that are either cancer or pre-cancerous. I can’t imagine your doctor wanting you to go into active surveillance with this.
At this point surgery or radiation are probably your only options since there is so much that needs to be removed. I don’t think I’d want to trust focal therapy, but you can talk to a doctor about it.
Since you don’t seem to have any aggressive issues, then five sessions of SBRT radiation may be all you need.
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Hug
3 ReactionsBest Wishes on determining the best treatment options.
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Hug
1 Reaction@malligood Well I've already spent most of the day with AI! Thanks for your response.
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Hug
1 Reaction@topf I agree. The days of surveillance are over for me.
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1 Reaction@wheel1 As is true for all of us it is quite the journey. I've got meetings with surgery oncologists and radiation oncologists scheduled over the next two weeks. I think the decipher is being ordered tomorrow. You mention the PET scan. Is that standard protocol for pathology results like mine? No one has mentioned it to me and none of my MRI's indicated any distant spread although EPE was a potential. Do you think it would help clarify decision making going forward?
@jeffmarc thanks. I've scheduled meetings with the radiation oncologists and surgeons. I'll also do a Decipher test. Where do you stand on a PET scan at this point? It has not been suggested to me at this point although on my last MRI EPE was "indeterminate".
@ezupcic
It actually may not be standard for favorable 7, I don’t know.