1. < Prostate Cancer
Profile picture for daveinflorida

Starting Orgovyx - how long for side effects to occur?

Posted by daveinflorida @daveinflorida, Feb 17, 2025

I've been taking Orgovyx for about 3 weeks and so far have zero side effects: no hot flashes, no fatigue or tiredness, no weight gain, no ED, nothing. I'm not complaining, but I'm on pins and needles waiting for stuff to start.

For background, I am in good shape and very active, I've been running for years and run 4-5 days a week, 30 - 35 miles, and also resistance train 2-3 days/week. I have no idea if that's what's doing it, but I'd be doing it anyway.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for jim18
jim18 | @jim18 | Oct 18 2:17pm
In reply to @johndattilo "40 radiation treatments and six months of ADT Orgovyx now diagnosed with low white cell counts!..." + (show)
Profile picture for johndattilo @johndattilo

40 radiation treatments and six months of ADT Orgovyx now diagnosed with low white cell counts! Caan i stop the Orgovyx?

Jump to this post

@johndattilo Discuss this with your Oncologist. Orgovyx usually causes a decrease in red cell counts, not white so Orgovyx may not be the cause. How many months have you been on Orgovyx and what is the treatment plan?

REPLY
1 reply
Profile picture for lm1
lm1 | @lm1 | Oct 18 2:36pm

anyone have heart issues when starting orgovyx? prolonged qt?

REPLY
1 reply
Profile picture for johndattilo
johndattilo | @johndattilo | Oct 18 3:55pm
In reply to @jim18 "@johndattilo Discuss this with your Oncologist. Orgovyx usually causes a decrease in red cell counts, not..." + (show)
Profile picture for jim18 @jim18

@johndattilo Discuss this with your Oncologist. Orgovyx usually causes a decrease in red cell counts, not white so Orgovyx may not be the cause. How many months have you been on Orgovyx and what is the treatment plan?

Jump to this post

@jim18 6 months but have a History of Feltys’ syndrome

REPLY
Profile picture for surftohealth88
surftohealth88 | @surftohealth88 | Oct 18 6:29pm
In reply to @johndattilo "40 radiation treatments and six months of ADT Orgovyx now diagnosed with low white cell counts!..." + (show)
Profile picture for johndattilo @johndattilo

40 radiation treatments and six months of ADT Orgovyx now diagnosed with low white cell counts! Caan i stop the Orgovyx?

Jump to this post

@johndattilo
Your white blood cells are low due to radiation. White blood cells are extremely sensitive to RT and die very fast. Also, RT effects production of new white blood cells since it stunts bone marrow in pelvic area where they are produced.

Patients usually recover WBC count in couple of months after RT , some need more time and very small percent have low WBC forever if RT damaged WBC stem cells.

My husband had both WBC and RBC effected by RT but both started rising and now 5 weeks later Neutrophils are normal count and RBC almost normal. He is taking immunity boosting vitamins and herbs and he also got B12 shot from his doctor which stimulates red cell production. This is of course not necessary, I just wanted to speed up recovery process for my husband and made sure he is doing all of this.

REPLY
Profile picture for rwells50
rwells50 | @rwells50 | Oct 19 8:19am

Hot flashes began in the first week of starting orgovyx and have continued since.

REPLY
Profile picture for Jeff Marchi
Jeff Marchi | @jeffmarc | Oct 19 10:53am
In reply to @lm1 "anyone have heart issues when starting orgovyx? prolonged qt?" + (show)
Profile picture for lm1 @lm1

anyone have heart issues when starting orgovyx? prolonged qt?

Jump to this post

@lm1
I had a lot of problems with abiraterone Because of it’s effect on the heart and QT. It caused me to have five afib events. I switched from Lupron and abiraterone to Orgovyx and Darolutamide And my afib events have stopped.

I’m not saying that the QT issue is completely resolved, But I don’t seem to be having afib so Orgovyx Doesn’t seem to be causing a problem.

REPLY
Profile picture for 10sweatherman
10sweatherman | @10sweatherman | Oct 20 7:21pm
In reply to @jime51 "@10sweatherman Keep making travel plans! I'm 4 months post completing 18 months of Orgovyx and had..." + (show)
Profile picture for jime51 @jime51

@10sweatherman Keep making travel plans! I'm 4 months post completing 18 months of Orgovyx and had 44 IMRT treatments for cancer in the prostate and nearby lymph nodes. Keep exercising, especially the resistance training, because ADT is known to cause muscle mass loss. About the question of side effects, I don't know. I had all of them in varying degrees with fatigue being the worst, but they seemed to have lessened a bit after a year of treatment. All the best!

Jump to this post

@jime51 Thank you for the positivity. I need that.

REPLY
Please sign in or register to post a reply.