@twitt1949 I can share with you my experience with 2 of the mutations from my MDS journey but I am not a Dr. With MDS, SF3B1 is considered low risk; RUNX1 is thought to increase the rate of disease relapse after a transplant. I do not know anything about PTPNII. I also don't know how the mutations affect AML. You need to ask your Dr. that question. I would ask him which mutation he is worried about. Did you have the mutations when you had MDS? It looks like your blood values are improving which is great!