@judpuds @katiekins I am sorry that the promising Camzyos did not/is not work(ing) for you. My cardiologist said and those who have contributed to the discussions on Connect have reported 3 possible outcomes: it's a miracle drug, it does nothing/side effects or it works for a while and then does not work. Reasons? No one seems to know at this point. I have a theory, but we stay away from speculation without supporting facts here on Connect.

@judpuds when you had your echo, were the results favorable? Has your cardiologist suggested that your body (those chemical factories we live in) may eventually adjust? Bisoporol is a beta blocker blood pressure drug while Camzyos is supposed to act on the thickness of the heart wall.

Have your doctors mentioned Myquorzo? Please try to get their opinions about trying that newer drug which is still under study.

I have no experience with either of these drugs, I had a septal myectomy at Mayo in July 2022, Camzyos was still in trial. I was 3 weeks shy of my 76th birthday and not for one single second have I ever regretted taking that step. Please keep in mind that your cardiologists may suggest other options, please also be sure that your care is provided at a COE or from a cardiologist very knowledgeable about HCM.

What are the next steps for you, @judpuds and @katiekins? When are your next appointments?