Anyone had prostate cancer spread to the lungs?

@jsemmerhoff

Hang in there, brother!

What was your PSA level after the biopsy? What happened to your testosterone levels over those three years? What was the trend for both PSA and testosterone?

In my opinion, having surgery to remove your prostate was a mistake.

Why didn't you switch from Zoladex to a different ADT drug over such a long period?

I’m certainly no doctor, but it seems to me you should discuss with your doctor switching your ADT medication to a different one and moving to Erleada or Nubeqa.

At one point, I was prescribed two additional courses of docetaxel, and my Zoladex was switched to a different ADT.

What is your mutation status?

Thank you Dennis.
My PSA has always been very low. At the time of the operation it was 8.0. Since then it has never been above 0.28. Even whith more then 20 tumors in my lungs. I will chech with my doctor next week regarding alternatives for Zoladex.

Jakob

@jsemmerhoff

If you are getting a Zoladex injection every three months, I think that’s a mistake, too. You need an injection every 28 days—using a different drug—or you should switch to Orgovyx. At the same time, ask to switch to Erleada. In other words, change your drug combination. And you need to do it quickly!

Honestly, I don’t understand why the extent of the disease is so widespread given such a low PSA level. Your PSA should be in the hundreds.

I too think surgery was the right option, particularly since the nodules were so few. Mine, unfortunately, were so widespread throughout the upper part of my left lung that they had to simply remove that section of the lung. The remaining nodules are relatively small and so far haven't grown with abiraterone and lupron.

@denis76
Zoladex has a long acting version that one gets every 12 weeks. Orgovyx would probably be better.

More than 10% of people don’t produce PSA. Neuroendocrine prostate cancer doesn’t produce any PSA.

@jsemmerhoff

Just wanted to say that our surgeon told us that aggressive cancers produce less PSA than indolent ones. My husband has aggressive cancer and his PSA was 7.6 at biopsy and 5.6 before surgery. His BCR was at 0.14 and PSMA even detected positive lymph nodes at that low PSA.

Wishing you the best of luck with future treatments and may you find the way to stop mets once and for all 🍀✨

@heavyphil
Yes, no mutations seems to be more good news than bad. I wish I could say the my treatment is not destined to get worse. My oncologist said he'd be happy to get two years out of the abiraterone and lupron and then there's a good chance the cancer will become hormone resistant and I'm off to the more life altering treatments. On the other hand, he also said he has one patient who is going on 10 years of hormone treatment being effective. I'm a Gleason score of 9 (5+4), so 10 years is probably wildly improbable! But you never know....

Tom, your diagnosis of prostate cancer in the lung has inspired me to bring this up with my oncologist. Since 6/16, age 70, when diagnosed I've had Proton radiation, numerous cancer drugs, pinpoint radiation to a rib, ending with Provenge (immunotherapy) in 12/23. Now at age 80.5, I'm cancer free.
The VA advised my cancer and heart conditions are Agent Orange related. I also have a mutated PLAB2 gene which could have been caused by Agent Orange. (jury is out on that). One function of PLAB2 gene is to control tumor growth. I passed the mutation to my daughter. Tom, were you, or perhaps your father, exposed to Agent Orange? I'm interested in possible generational Agent Orange contamination. The Vietnam Veterans of America is addressing this issue. I have no prostate cancer in my family history.
Tom, since the immunotherapy in 2023 (Provenge), my cancers are in remission. All cancer journeys are unique. I pray your cancer journey is positive and you have many more quality years.
John

Thanks for your story. It's quite inspiring to hear you are now cancer free.

No, neither I or anyone in my family has been exposed to Agent Orange, so I guess my cancer is just the luck of the draw. I was in remission for 5 years before it came back and spread, so hopefully my story going forward ends as good as yours did!

@florida11
Were these the only two nodules? If so, it's great that got them all. Mine were pretty widespread throughout my left lung, which is why they did a lung resection and removed part of it. Like you, my PSA was nearly undetectable when my PET scan lit up like a Vegas neon sign. I'm a Gleason score of 9 (5+4) and we're hoping to get at least two years out of the abiraterone and Lupron before the cancer becomes resistant. Good luck going forward and I hope those were the only two nodules.