Yes. I have had chronic sinusitis since 1984 until just now. I was contaminated with pseudomonus at some point with early surgeries. I have had increasingly dufficult infections. Long story short, the fifth doc performed more surgery finding infection in the bones. Consequently much tissue and bone removed from nasal and sinuses. Turbinates reduced, bone fragments removed, sigmoid opened up again. Many antibiotics used in nasal rinses twice a day with cortisone. Then 61 infusions of Ceficipime. Then levofloxine in nasal rinses for weeks at a time. Still found infection. I began to swab with colloidal silver, serrapaptase, and lysine. Twice a day following sinus rinsing. Finally got rid of the last infection after 3.5 years. Actually healed by God. Good luck. Don’t give up.