@gillispie7
Oh my gosh, your poor husband! Can’t imagine how awful he feels on a daily basis with vomiting, fatigue and dizziness. No wonder he’s feeling depressed!
It’s great that the meds are working to keep his CML under control but his quality of life is certainly not reflected in this success!

You mentioned he wasn’t having any issues on the non-generic Gleevec. While generic drugs contain the same active ingredients and are required to meet the same standards for safety, effectiveness, and quality, I’ve found in my own health that there are differences. There was a drug that I was taking in my own health journey. I reacted horribly to the generic version. My doctor wrote a narrative to the insurance company and I was able to get the brand named drug covered. No issues after that.
Sometimes we have to be the squeaky wheel!

There are also other medications for CML such as Imatinib (Gleevec, Imkeldi)
Nilotinib (Tasigna, Danziten)
Dasatinib (Sprycel)
Bosutinib (Bosulif)
Asciminib (Scemblix).
Each person has their own chemistry and some meds work better for some people than others. Often when there are side effects with one drug, switching may help alleviate the issues.

I’m sure you’ve discussed these ongoing, debilitating side effects with your husband’s doctors. Are they not concerned?