New promising osteoporosis treatment (phase 1 trial results)

I will never take another Prolia injection , thats for sure

Thanks, @heavyphil.
While promising, there are a few important things to note about this study:
Phase I Clinical Trial To Evaluate The Intravenous Infusion Of Autologous Fucosylated Bone Marrow Mesenchymal Cells Therapy In Patients With Established Osteoporosis and Low Impact Fractures https://clinicaltrials.gov/study/NCT02566655

It is a phase 1 study that was conducted on only 10 women. Next step is a phase 2 trial.

More about phases of a clinical trial here: https://www.mayoclinic.org/departments-centers/mayo-clinic-cancer-center/cancer-care/about-cancer-clinical-trials

Let's hope research continues to shine a bright light on a promising new treatment.

heavyphil, the microscopic photo of trabecular bone gives your post even more value than that definitely exciting study. Thanks

@gently Thanks, bud…it seems that most of the drugs currently available do NOT re-trabeculate or rebuild the scaffolding that gives bone its resiliency.
It remineralizes the bone, but it is more of a veneering effect than a structural one; I mean, these drugs can cause spontaneous fractures of long bones, so something is definitely lacking there, right?
My wife is currently using Fortibone collagen peptides which are supposed to aid in rebuilding the scaffolding, along with Vit D , Magnesium and Calcium.
But this new research is pretty exciting (though small in scope) so the next phase is pretty important.
🤞🤞
Phil

heavyphil, more of a veneering effect is well phrased. Only two of the current medications produce chondrocytes to rebuild the trabecular structure.
The fortibone studies, not on comparable standards to the FDA approved clinicals, improved the bone marker for bone acquisition, P1NP, by 11% after a year compared to a control group not taking any collagen supplement. Tymlos or Forteo typically increase P1NP by 100 to 200% after 2 months. If you incorporate the LSC you have an increase of 5 or 6%, Fortibone didn't require a washout period before the draw other than the 8 hour fast which would raise the % a bit.
Collagen is a valuable addition and Fortibone is a good collagen. We don't know if it is better than a less expensive collagen. The placebo group was collagen free.
I'm on extended Forteo and tend to recommend it with enthusiasm.
I like men who look out for their wives.

Just to point out a potential risk of undetected Osteoporosis.
My hospital had decided that their DEXA scans only needed to look at the left humorous and right femur.
So almost two years after 12 months of Lupron I got 5 compression fractured, thoracic vertebrae. Extremely painful requiring two surgeries (kyphectomy) to stabilize them.
From now on I'll take lots of vitamin D3 and C and a bone building vitamin that sounds like the ingredients of Fortibone. My Ca is and has been very good.
Good luck to all of you who are at risk.

@gently Well believe it or not, it was some of YOUR postings about OP that led me down the path to Fortibone.🤗
You stressed the need for an anabolic and although my wife didn’t want Forteo, she had no problem with this collagen supplement; I ‘think?’ It is the only one which has been clinically tested (with results) but I am sure there are others.
So, many thanks for your help and I hope your bones are hard as rock!
Best,
Phil

I don’t want to hijack your thread Phil, but just want to say to anyone embarking on ADT treatment needs to have a baseline DEXA scan done. I asked for one, and my results said I had osteoporosis. I would have never known, had I not asked.

Thanks for posting the trial results.

Forbes.com is not 'exactly' a renown medical journal...

@oldmariner Simply click on ‘the study’ and it will take you to the original article which appeared in the scientific journal CELL.
You can thank me later for posting the Forbes condensed version, written in layman’s terms, rather than the original study which is unreadable unless you have a PhD in cell biology. Best,
Phil