I take my thyroid in the middle of the night when I get up to pee (side effect of Tymlos) around 3 or 4 am. I inject Tymlos at 3pm. Works out pretty well. My Dr actually reduced my thyroid dosage without any increase in symptoms (TSH bloodwork okay so far) because it can contribute to bone loss as well. I mainly started this night meds routine because I could not space all the other supplements far enough apart (2 hours each) from each others and sometimes food. I have the med and water set up on my bedside table each evening. I hope you are able to find something that works for you!