@mumblipeg Yea! I wear old lady support socks and it helps! My toes will cramp and freeze up any time I flex them in any direction, annoying! My doctor says platelets under 600 is acceptable if I haven’t had any issues or clots. I stick around 400 They jump around and I take 500 mg six days a week.I have PV JAK2 and just turned 60, female. It ain’t easy. I get a lot of tooth pain from the meds but I just deal as the other meds have many more side effects and are extremely expensive.