@mulle I was diagnosed with CLL four years ago (at age 69). My main issues during watch and wait were fatigue, very swollen lymph nodes , and frequent lung infections that got progressively worse. When it really affected my activity levels (I'm an avid hiker), I opted for treatment. My pulmonary issues got worse with my treatment until I needed supplemental oxygen and my Oncologist stopped the Venclexta. A visit to Mayo uncovered the Cystic Fibrosis and Bronchiectasis as well as my severe immune deficiency. I currently take Brinsupri for the Bronchiectasis and Pulmozyme for the CF along with my AWC. I'm back to hiking, did a half-marathon in Acadia in June and will do the Mammoth March in Georgia next month. So, there is life after diagnosis and treatment! Good luck to you in your journey.