Hello @dhafford, Welcome to Connect. I'm hoping your upcoming appointment will finally provide some guidance and a treatment/management plan to help you get some relief from restless leg syndrome. It sounds like you have tried a lot of different treatments without much relief. Have you tried any of the lifestyle and home remedies or coping and support suggestions listed on the Mayo Clinic site? - https://www.mayoclinic.org/diseases-conditions/restless-legs-syndrome/diagnosis-treatment/drc-20377174.

Hi I've also had RLS for 45 plus years and have had a reaction to the medication use to treat RLS so that's out for me. Mine will start early evening and throughout the night. I've worn holes in sheets several times over the years. I do take magnesium glycinate but have not really noticed a difference. My Iron is good, but one doctor had me take extra for a while to see if that helped but stopped when it was ineffective. I did have one neurologist tell me that while my iron levels are good, my brain might not be receiving the signal that my iron is good. Not much can be done with that, and I moved out of the area before I could discuss that with him in more detail. I have another appointment in Dec with a different neurologist so will see what they say. My problem is I try to find doctors that are good with RLS and only after seeing them do I find out they really know nothing and just want to prescribe meds, which I cannot take. I take tramadol which doesn't stop it but helps makes it more tolerable. What works the best for me is heat on my back, tramadol, and pot gummies. I do the CBD with little THC as I don't want to get high. At first, it worked wonders for a few months, but now it's back to bothering more often. I really don't want to take more and more gummies so thinking I might stop for a month then start back. I really hope this new doctor in Dec can help me....triggers for me have been too much walking and too little walking, being tired always seems like it will make it worse. Mine is to the point my arms will sometimes bother me so that just makes it extra special...lol what helps today will not tomorrow as it's hit and miss what will work that day but I use tramadol, heat, support sock, walking (not too much), gummies, laying on couch over chair etc. the supplements I take never seemed to make a difference, but I still take them as afraid it might be worse without but over the years doctors have said...Vitamin D, E, Magnesium, I have always taken potassium as I also get leg cramps all the time as did my mother. FYI some medications will give me sever leg cramps to the point I cannot take...I actually have a long list of things I cannot take as I have a reaction to it...hives, leg cramps, cough and asthma symptoms (Aleve and other medications) or taste perversion (omega 3). I say this as many people here have suggested different medications or vitamin's and I've tried many, but have reactions and end up not being able to take them so back to what works the best most of the time is heat, tramadol, gummies and support socks. good luck to you...

@dhafford Nidra straps

@dhafford
Hi There,
Have you had a sleep study?
You have gone through the ramifications of medications, and what many of us sufferers have. experienced, augmentation, or nothing.
What neurologist have you seen?
After almost 35-40 years suffering from a form of RLS, called PLMD:
Periodic Limb Movement Disorder, the neurologist from Mayo who is a Sleep specialist, prescribed buprenorphine subloxene, dissolved under the tongue.
What a Difference! It is only prescribed at 2mg, but I take 1/3 of a tablet.
It has kept the leg spasms at bay.
My best to you.