What treatment helps for feet neuropathy?

Posted by corneliagd @corneliagd, Aug 27, 2025

Hello,
I am looking for years for some medical treatment to ease my neuropathic pain in my feet. It is getting worse especially at night: pain and burning of my soles, numbness and tingling.
What I am taking now, with modest results, are Naproxen and Magnesium Glycinate.
What about you? What is your medication for flair ups?

Interested in more discussions like this? Go to the Neuropathy Support Group.

Profile picture for brennankb55 @brennankb55

@corneliagd ~ I've had neuropathy in my feet that started getting really painful about 10 years ago. For the past 4 years, I've been taking Lyrica (75mg 3x/day) because nothing else worked until recently. I started taking low dose Naltrexone (LDN) in June - 1.5mg titrating to 4.5mg. Currently I'm taking 2.5mg once a day, but have a new prescription for 3.5mg. Already, it has almost completely eliminated the burning, tingling and sharp stabbing pain in my toes and balls of my feet!! And I haven't had to use any of the topicals or anything else! Believe me, I've tried it all to get relief over the years.

Many doctors aren't aware yet that LDN is being used "off label" to treat chronic pain of various kinds, including neuropathic pain. At higher doses (50mg and up) it is used to treat opoid addiction. LDN has to come from a compounding pharmacy (not CVS or a drug store or grocery pharmacy) and requires a prescription. Side effects listed for it are minimal and resolve quickly (mild nausea or "vivid dreams"), but I've had NO side effects at all. It doesn't lead to any weight gain and fatigue the way Lyrica and Gabapentin do, nor is it addictive. I'm hopeful that by the time I get to the 4.5mg dose, I'll be able to wean off of Lyrica completely. But so far, I'm really happy that the LDN is working so well to relieve my pain!! I'm happy to answer any other questions about my experience with LDN. Best wishes to you!

P.S. - It's not exactly inexpensive. I pay $110 for a 90-day supply. But considering all of the money I've spent on topicals, vitamins, supplements, you name it, to me it's worth it because it's working! I've stopped taking the ALA, magnesium glycinate, everything, and swear by LDN! It's FDA approved for treating chronic pain. The websites that reference it are as follows:
* https://www.clevelandclinicmeded.com/showcase/EKCC138/docs/1430_Hill_Dose.pdf
* https://ldnresearchtrust.org/

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@brennankb55 thank you so much for your detailed answer. I will mention for sure this medicine to my neurologist and hope I could get a prescription. Lately what bothers me most is the burning in my toes and front feet, more than the pain. I really hope to find some relief with this medicine. Thank you and all the best

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Profile picture for brennankb55 @brennankb55

@corneliagd ~ I've had neuropathy in my feet that started getting really painful about 10 years ago. For the past 4 years, I've been taking Lyrica (75mg 3x/day) because nothing else worked until recently. I started taking low dose Naltrexone (LDN) in June - 1.5mg titrating to 4.5mg. Currently I'm taking 2.5mg once a day, but have a new prescription for 3.5mg. Already, it has almost completely eliminated the burning, tingling and sharp stabbing pain in my toes and balls of my feet!! And I haven't had to use any of the topicals or anything else! Believe me, I've tried it all to get relief over the years.

Many doctors aren't aware yet that LDN is being used "off label" to treat chronic pain of various kinds, including neuropathic pain. At higher doses (50mg and up) it is used to treat opoid addiction. LDN has to come from a compounding pharmacy (not CVS or a drug store or grocery pharmacy) and requires a prescription. Side effects listed for it are minimal and resolve quickly (mild nausea or "vivid dreams"), but I've had NO side effects at all. It doesn't lead to any weight gain and fatigue the way Lyrica and Gabapentin do, nor is it addictive. I'm hopeful that by the time I get to the 4.5mg dose, I'll be able to wean off of Lyrica completely. But so far, I'm really happy that the LDN is working so well to relieve my pain!! I'm happy to answer any other questions about my experience with LDN. Best wishes to you!

P.S. - It's not exactly inexpensive. I pay $110 for a 90-day supply. But considering all of the money I've spent on topicals, vitamins, supplements, you name it, to me it's worth it because it's working! I've stopped taking the ALA, magnesium glycinate, everything, and swear by LDN! It's FDA approved for treating chronic pain. The websites that reference it are as follows:
* https://www.clevelandclinicmeded.com/showcase/EKCC138/docs/1430_Hill_Dose.pdf
* https://ldnresearchtrust.org/

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@brennankb55
Have you tried nortryptaline?

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Profile picture for brennankb55 @brennankb55

@corneliagd ~ I've had neuropathy in my feet that started getting really painful about 10 years ago. For the past 4 years, I've been taking Lyrica (75mg 3x/day) because nothing else worked until recently. I started taking low dose Naltrexone (LDN) in June - 1.5mg titrating to 4.5mg. Currently I'm taking 2.5mg once a day, but have a new prescription for 3.5mg. Already, it has almost completely eliminated the burning, tingling and sharp stabbing pain in my toes and balls of my feet!! And I haven't had to use any of the topicals or anything else! Believe me, I've tried it all to get relief over the years.

Many doctors aren't aware yet that LDN is being used "off label" to treat chronic pain of various kinds, including neuropathic pain. At higher doses (50mg and up) it is used to treat opoid addiction. LDN has to come from a compounding pharmacy (not CVS or a drug store or grocery pharmacy) and requires a prescription. Side effects listed for it are minimal and resolve quickly (mild nausea or "vivid dreams"), but I've had NO side effects at all. It doesn't lead to any weight gain and fatigue the way Lyrica and Gabapentin do, nor is it addictive. I'm hopeful that by the time I get to the 4.5mg dose, I'll be able to wean off of Lyrica completely. But so far, I'm really happy that the LDN is working so well to relieve my pain!! I'm happy to answer any other questions about my experience with LDN. Best wishes to you!

P.S. - It's not exactly inexpensive. I pay $110 for a 90-day supply. But considering all of the money I've spent on topicals, vitamins, supplements, you name it, to me it's worth it because it's working! I've stopped taking the ALA, magnesium glycinate, everything, and swear by LDN! It's FDA approved for treating chronic pain. The websites that reference it are as follows:
* https://www.clevelandclinicmeded.com/showcase/EKCC138/docs/1430_Hill_Dose.pdf
* https://ldnresearchtrust.org/

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@brennankb55 as well as having periphery neuropathy, I have neck pain caused from arthritis. I am on 100mg Lyrica 3 times a day which helps but does not take all the pain away. I am going to ask my doctor about LDN but is seems a bit complicated to me and I don’t know if it will work for neck nerve pain but maybe worth a try. I have had ablations and injections which don’t work anymore

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Profile picture for smueller19 @smueller19

@johnbishop
Upon diagnosis, my neurologist said there was nothing he could for it. He ordered Gabapentin, I took it three weeks. It made me loopy and masked the pain but did nothing for the neuropathy,
I researched neuropathy and found a chiropractor certified in neuropathy. I do two treatments twice daily: ReBuilder electrical stimulation and Anodyne infrared lights, In addition, two supplements of Vasopro and Greensberry. At first I had biweekly chiropractor visits consisting of manipulation, spinal decompression. Vibration platform, and Denner Roll which are helpful.

Now I have weekly visits. It was pricey, but I wasn’t screaming in pain. Again, it manages the pain.

I am contemplating ordering Neuro Salt, developed by Dr OZ. The ads say it cures neuropathy.

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@smueller19
Do not buy Neuro Salt, it's a SCAM, not endorsed by Dr. Oz or Dr. Phil
It does NOT WORK!

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Profile picture for adria36 @adria36

It’s really frustrating not to know if a false AI response with a real Doctor is legitimate. Scary

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I have purchased an electrical foot stimulator on Amazon. It seems to relieve some of the numbness in my feet. I try to use it twice a day while watching TV, 30 minutes each time. As an elderly lady I have to turn it up to 18 or 20 to feel the intensity I want. It is called a Tens & EMS Foot Muscle Stimulator. There is no brand name. It is round, white with black foot shapes and control buttons between the footprints. It has different modes and different intensities. Don't know if it will help others, but it helps me. It costs around $100.

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I am 75 and active with feeding and caring for horses. Consequently, my feet started burning, I couldn’t sleep all night. What is best cure for pain and a way to reverse this condition?

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Profile picture for aliceruthcrowley @aliceruthcrowley

I am 75 and active with feeding and caring for horses. Consequently, my feet started burning, I couldn’t sleep all night. What is best cure for pain and a way to reverse this condition?

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Hello @aliceruthcrowley, Welcome to Connect. You will notice that we merged your post with an existing discussion so that you could learn what others have shared that helps with the burning pain at night. If you click the link below, it will take you to the beginning of the discussion:
-- What treatment helps for feet neuropathy?: https://connect.mayoclinic.org/discussion/treatment-for-periferic-neuropathy/

You mentioned in another discussion that you apply pressure on your feet with your thumb roughly one inch below your toes in the center daily and also put magnesium on your feet and wrist area to help you sleep at night. How long have you been doing this? Does it help with the burning?

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Profile picture for aliceruthcrowley @aliceruthcrowley

I am 75 and active with feeding and caring for horses. Consequently, my feet started burning, I couldn’t sleep all night. What is best cure for pain and a way to reverse this condition?

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@aliceruthcrowley If it's neuropathy(nerve damage) it can't be "reversed", it's permanent.

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Anyone dealing with neuropathy in the feet and have any suggestions on how to get some relief? At times it hurts so bad I can walk and need to sit. Also because I have neuropathy and numbness I loose balance and almost fall at times which is dangerous.

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Profile picture for aliceruthcrowley @aliceruthcrowley

I am 75 and active with feeding and caring for horses. Consequently, my feet started burning, I couldn’t sleep all night. What is best cure for pain and a way to reverse this condition?

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@aliceruthcrowley You need to have a pain doc to a few tests to see what the cause of your pain is. Then you should be able to get an idea of how to proceed with pain meds. I wish you well in your search.

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